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Vitamin B6 metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
2-(Hydroxymethyl)-3-(acetamidomethylene)succinate + H2O + H+ <=> 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO2 + NH3 3.5.1.66 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase

pyridoxine_5''-phosphate + H2O <=> pyridoxine + phosphate 3.1.3.2 acid phosphatase
3.1.3.74 pyridoxal phosphatase


1-deoxy-D-xylulose_5-phosphate + 3-amino-1-hydroxyacetone_1-phosphate <=> H+ + pyridoxine_5''-phosphate + phosphate + H2O 2.6.99.2 pyridoxine 5'-phosphate synthase

pyridoxamine + O2 + H2O <=> pyridoxal + NH3 + H2O2 1.4.3
1.4.3.5 pyridoxal 5'-phosphate synthase


pyridoxal + ATP <=> pyridoxal_5''-phosphate + H+ + ADP 2.7.1.35 pyridoxal kinase

4-phospho-D-erythronate + NAD+ <=> H+ + 3-hydroxy-2-oxo-4-(phosphonooxy)butanoate + NADH 1.1.1.290 4-phosphoerythronate dehydrogenase

D-erythrose_4-phosphate + NAD+ + H2O <=> 4-phospho-D-erythronate + NADH + H+ 1.2.1.72 erythrose-4-phosphate dehydrogenase

pyridoxamine + 2-oxoglutarate <=> pyridoxal + D-glutamate 2.6.1.31 pyridoxamine---oxaloacetate transaminase
2.6.1.54 pyridoxamine-phosphate transaminase


pyridoxine + O2 <=> Isopyridoxal + H2O2 1.1.99.9 pyridoxine 5-dehydrogenase

3-Hydroxy-2-methylpyridine-5-carboxylate + NADPH + H+ + O2 <=> 2-(Acetamidomethylene)succinate + NADP+ 1.14.13.242 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase

H+ + 3-hydroxy-2-methylpyridine-4,5-dicarboxylate <=> CO2 + 3-Hydroxy-2-methylpyridine-5-carboxylate 4.1.1.51 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase

4-phosphooxy-L-threonine + H2O <=> L-4-hydroxythreonine + phosphate 4.2.3
4.2.3.1 threonine synthase


pyridoxal + NAD+ <=> 4-Pyridoxolactone + NADH + H+ 1.1.1.107 pyridoxal 4-dehydrogenase

ATP + pyridoxamine <=> H+ + ADP + pyridoxamine_5''-phosphate 2.7.1.35 pyridoxal kinase
2.7.1.49 hydroxymethylpyrimidine kinase


O2 + H2O + pyridoxamine_5''-phosphate <=> NH3 + H2O2 + pyridoxal_5''-phosphate 1.4.3.5 pyridoxal 5'-phosphate synthase

5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + H2O + NAD+ <=> 3-hydroxy-2-methylpyridine-4,5-dicarboxylate + NADH + H+ 1.2.1.100 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase

D-ribose_5-phosphate + D-glyceraldehyde_3-phosphate + L-glutamine <=> pyridoxal_5''-phosphate + L-glutamate + 3 H2O + phosphate 4.3.3.6 pyridoxal 5'-phosphate synthase (glutamine hydrolysing)

4-pyridoxate + acceptor <=> 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + reduced_acceptor 1.1.99.42 4-pyridoxic acid dehydrogenase

Isopyridoxal + NAD+ + H2O <=> nicotinate + NADH + H+ 1.2.1.102 isopyridoxal dehydrogenase (5-pyridoxate-forming)

pyridoxamine_5''-phosphate + 2-oxoglutarate <=> pyridoxal_5''-phosphate + D-glutamate 2.6.1.54 pyridoxamine-phosphate transaminase

H2O + 4-Pyridoxolactone <=> H+ + 4-pyridoxate 3.1.1.27 4-pyridoxolactonase

pyridoxine <=> 1-deoxy-D-xylulose + L-4-hydroxythreonine not assigned

ATP + pyridoxine <=> H+ + ADP + pyridoxine_5''-phosphate 2.7.1.35 pyridoxal kinase
2.7.1.49 hydroxymethylpyrimidine kinase


(2S)-2-amino-3-oxo-4-phosphonooxybutanoate + H+ <=> 3-amino-1-hydroxyacetone_1-phosphate + CO2 0.0.0.0
1.1.1.262 4-hydroxythreonine-4-phosphate dehydrogenase


pyridoxamine_5''-phosphate + H2O <=> pyridoxamine + phosphate 3.1.3.2 acid phosphatase
3.1.3.74 pyridoxal phosphatase


4-phosphooxy-L-threonine + 2-oxoglutarate <=> 3-hydroxy-2-oxo-4-(phosphonooxy)butanoate + L-glutamate 2.6.1.52 phosphoserine transaminase

nicotinate + O2 + NADPH <=> 2-(Hydroxymethyl)-3-(acetamidomethylene)succinate + NADP+ 1.14.13.241 5-pyridoxate monooxygenase

glycolaldehyde + 2-oxobutyrate + L-alanine <=> pyridoxine not assigned

3-hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate <=> 5-Pyridoxolactone + H2O not assigned

O2 + H2O + pyridoxal <=> H+ + H2O2 + 4-pyridoxate 1.2.3.1 aldehyde oxidase
1.2.3.8 pyridoxal oxidase


pyruvate + pyridoxamine <=> L-alanine + pyridoxal 2.6.1.30 pyridoxamine---pyruvate transaminase

pyridoxamine + oxaloacetate <=> pyridoxal + L-aspartate 2.6.1.31 pyridoxamine---oxaloacetate transaminase

3-Hydroxy-2-methylpyridine-5-carboxylate + NADH + H+ + O2 <=> 2-(Acetamidomethylene)succinate + NAD+ 1.14.13.242 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase

pyridoxine + O2 <=> pyridoxal + H2O2 1.1.3.12 pyridoxine 4-oxidase
1.4.3.5 pyridoxal 5'-phosphate synthase


Isopyridoxal + NAD+ <=> 5-Pyridoxolactone + NADH + H+ 1.1.1.416 isopyridoxal dehydrogenase (5-pyridoxolactone-forming)

4-(phosphonooxy)-L-threonine + NAD+ <=> 2-amino-3-oxo-4-phosphonooxybutyrate + NADH 1.1.1.262 4-hydroxythreonine-4-phosphate dehydrogenase

O2 + pyridoxine_5''-phosphate <=> H2O2 + pyridoxal_5''-phosphate 1.4.3.5 pyridoxal 5'-phosphate synthase

pyridoxal_5''-phosphate + H2O <=> pyridoxal + phosphate 3.1.3.2 acid phosphatase
3.1.3.26 4-phytase
3.1.3.74 pyridoxal phosphatase
3.1.3.8 3-phytase




NADP+ + pyridoxine <=> H+ + NADPH + pyridoxal 1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.65 pyridoxine 4-dehydrogenase


2-(Acetamidomethylene)succinate + 2 H2O <=> acetate + succinate_semialdehyde + NH3 + CO2 3.5.1.29 2-(acetamidomethylene)succinate hydrolase
3.5.1.66 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase


Visualization of the pathway